IHydroxypropyl methylcellulose(Igama le-INN:I-Hypromelulose), nayo ifushanisiwe ngokuthii-hydroxypropyl methylcellulose (I-HPMC), izinhlobonhlobo zama-non ionic cellulose ether exubile. Kuyi-semi synthetic, engasebenzi, i-viscoelastic polymer evame ukusetshenziswa njengesithambisi ku-ophthalmology, noma njengesengezo noma isamukeli emithini yomlomo, evame ukutholakala ezinhlotsheni ezahlukahlukene zempahla.
Njengesengezo sokudla, i-hydroxypropyl methylcellulose ingadlala izindima ezilandelayo: i-emulsifier, i-thickener, i-suspension agent, kanye nokuthatha indawo ye-gelatin yezilwane. Ikhodi yayo ye-Codex Alimentarius ithi E464.
impahla yamakhemikhali
Umkhiqizo oqediwe wei-hydroxypropyl methyl celluloseiyimpushana emhlophe noma emhlophe exegayo eqinile ene-fibrous, enosayizi wezinhlayiyana odlula esisefweni esinezikhala ezingama-80. Izilinganiso ezihlukene zokuqukethwe kwe-methoxy ne-hydroxypropyl kanye ne-viscosity yomkhiqizo oqediwe kwenza kube izinhlobonhlobo zezinhlobonhlobo ezinomehluko ekusebenzeni. Inezici zokuncibilika emanzini abandayo futhi ayincibiliki emanzini ashisayo afana ne-methylcellulose, futhi ukuncibilika kwayo kuzinyibilikisi zemvelo kudlula okwamanzi. Ingancibilika ku-anhydrous methanol kanye ne-ethanol, kanye nama-hydrocarbon ane-chlorinated njenge-dichloromethane, i-trichloroethane, nezinyibilikisi eziphilayo njenge-acetone, isopropanol, ne-diacetone alcohol. Lapho incibilika emanzini, ihlangana nama-molecule amanzi ukuze kwakheke i-colloid. Iqinile kuma-acids nezisekelo futhi ayithinteki phakathi kwebanga le-pH lika-2-12. Nakuba i-hydroxypropyl methylcellulose ingenabo ubuthi, iyavutha futhi ingasabela ngobudlova ngama-oxidants [5].
I-viscosity yeImikhiqizo ye-HPMCukwanda ngokunyuka kokugxila kanye nesisindo samangqamuzana. Lapho izinga lokushisa likhuphuka, i-viscosity iqala ukwehla. Lapho izinga lokushisa lifinyelela izinga elithile lokushisa, i-viscosity iphakama ngokuzumayo futhi i-gel ivele. Izinga lokushisa lejeli lemikhiqizo ye-viscosity ephansi liphakeme kunemikhiqizo ye-viscosity ephezulu. Isixazululo saso esinamanzi sizinzile ekamelweni lokushisa futhi ngokuvamile asinakho ukuwohloka kwe-viscosity ngaphandle kokuwohloka kwe-enzymatic. Inezici ezikhethekile ze-thermal gelling, ukusebenza okuhle kokwenza ifilimu nomsebenzi ongaphezulu.
Ukulungiselela
Ngemuva kokuthi i-cellulose ilashwe nge-alkali, i-alkoxy anion ekhiqizwa i-hydroxyl deprotonation ingangezwa ku-epoxy propane ukuze ikhiqize.i-hydroxypropyl cellulose ether; Ingakwazi futhi ukujiya nge-methyl chloride ukukhiqiza i-methyl cellulose ether. Lapho kokubili ukusabela kwenzeka kanyekanye,i-hydroxypropyl methyl cellulosekukhiqizwa.
inhloso
Ukusetshenziswa kwei-hydroxypropyl methyl celluloseiyafana nezinyei-cellulose ethers, ikakhulukazi esetshenziswa njenge-dipersant, i-ejenti yokumiswa, i-thickener, i-emulsifier, i-stabilizer, ne-adhesive emikhakheni ehlukahlukene. Iphakeme kunamanye ama-ether e-cellulose ngokuya nge-solubility, dispersibility, transparency, kanye nokumelana nama-enzyme.
Embonini yokudla neyokwenza imithi, isetshenziswa njengesengezo. Ngenxa yezakhiwo zayo zokunamathisela, izakhiwo zefilimu, ukuqina nokuhlakazeka oketshezini, kanye nekhono layo lokuvimbela ukungena kwamafutha nokugcina umswakama, isetshenziswa njenge-adhesive, thickener, dispersant, reliever, stabilizer, ne-emulsifier. Ayinabo ubuthi, ayinayo inani lokudla okunempilo, futhi ayinazo izinguquko ze-metabolic.
Ngaphezu kwalokho,I-HPMCinezinhlelo zokusebenza ekuphenduleni kwe-synthetic resin polymerization, amakhemikhali e-petrochemical, i-ceramics, ukwenza iphepha, isikhumba, izimonyo, okokunamathela, izinto zokwakha, namapuleti okuphrinta azwela izithombe.
Isikhathi sokuthumela: Sep-04-2023